사이토글로빈은 모든 조직에서 발현되며, 특히 해양 포유류에서 가장 많이 활용되는 글로빈 분자이다. 사이토글로빈은 2001년에 발견되었으며,[6] 2002년에 사이토글로빈으로 명명되었다.[7] 사이토글로빈은 저산소증으로부터 보호하는 역할을 하는 것으로 생각된다. 사이토글로빈의 예상되는 기능은 동맥혈에서 뇌로 산소를 전달하는 것이다.[8]
↑Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N (Feb 2014). “Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver”. 《Laboratory Investigation》 94 (2): 192–207. doi:10.1038/labinvest.2013.135. PMID24296877.
Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M, Yoshizato K (Sep 2002). “Characterization of human stellate cell activation-associated protein and its expression in human liver”. 《Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression》 1577 (3): 471–5. doi:10.1016/s0167-4781(02)00477-3. PMID12359339.
Sawai H, Kawada N, Yoshizato K, Nakajima H, Aono S, Shiro Y (May 2003). “Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans”. 《Biochemistry》 42 (17): 5133–42. doi:10.1021/bi027067e. PMID12718557.
de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M (Feb 2004). “Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination”. 《Journal of Molecular Biology》 336 (4): 917–27. doi:10.1016/j.jmb.2003.12.063. PMID15095869. S2CID21144924.
Sugimoto H, Makino M, Sawai H, Kawada N, Yoshizato K, Shiro Y (Jun 2004). “Structural basis of human cytoglobin for ligand binding”. 《Journal of Molecular Biology》 339 (4): 873–85. doi:10.1016/j.jmb.2004.04.024. PMID15165856.
Hamdane D, Kiger L, Dewilde S, Uzan J, Burmester T, Hankeln T, Moens L, Marden MC (Apr 2005). “Hyperthermal stability of neuroglobin and cytoglobin”. 《The FEBS Journal》 272 (8): 2076–84. doi:10.1111/j.1742-4658.2005.04635.x. PMID15819897. S2CID13377138.
Sawai H, Makino M, Mizutani Y, Ohta T, Sugimoto H, Uno T, Kawada N, Yoshizato K, Kitagawa T, Shiro Y (Oct 2005). “Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin”. 《Biochemistry》 44 (40): 13257–65. doi:10.1021/bi050997o. PMID16201751.
McRonald FE, Liloglou T, Xinarianos G, Hill L, Rowbottom L, Langan JE, Ellis A, Shaw JM, Field JK, Risk JM (Apr 2006). “Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression”. 《Human Molecular Genetics》 15 (8): 1271–7. doi:10.1093/hmg/ddl042. PMID16510494.
Xinarianos G, McRonald FE, Risk JM, Bowers NL, Nikolaidis G, Field JK, Liloglou T (Jul 2006). “Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer”. 《Human Molecular Genetics》 15 (13): 2038–44. doi:10.1093/hmg/ddl128. PMID16698880.
