Talk:Protamine

Medicine Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine
Low	This article has been rated as Low-importance on the project's importance scale.

Molecular Biology: MCB

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of molecular biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology
???	This article has not yet received a rating on the project's importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Low-importance).

Pharmacology Mid‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology
Mid	This article has been rated as Mid-importance on the project's importance scale.

PHIT/HIT

doi:10.1111/jth.13405 - protamine administration increases risk of antibodies against the protamine-heparin complex and can result in a HIT-like state. JFW | T@lk 16:29, 28 September 2016 (UTC)[reply]

Error message

"Cite error: The named reference "refGRCh38Ensembl" was defined multiple times with different content (see the help page)." - User:Boghog writes here that the template {{infobox gene}} "is meant to be used once and only once per article". Wakari07 (talk) 15:15, 17 March 2020 (UTC)[reply]

Fixed I have moved the {{infobox gene}} boxes to newly created gene specific PRM1 and PRM2 pages and restored the {{infobox protein}} boxes with embedded links to the the new pages. Boghog (talk) 15:55, 17 March 2020 (UTC)[reply]

Thank you and kudos for the expertise. Wakari07 (talk) 18:33, 17 March 2020 (UTC)[reply]

Note about structure and fringe theories

This is just a note on why I've removed the Biegeleisen 2006 reference. The reference conflicts so significantly with the other proposed models (both for protamine and for DNA), as well as with experimental evidence, that I think it's reasonable to omit as a fringe position. The author of that theory has shown interest in forwarding fringe topics on some other pages.

I think it's therefore sensible to be cautious about any re-addition of the following references without significant consensus:

Biegeleisen, Ken (2006-08). "The probable structure of the protamine–DNA complex". Journal of Theoretical Biology. 241 (3): 533–540. doi:10.1016/j.jtbi.2005.12.015. ISSN 0022-5193. {{cite journal}}: Check date values in: |date= (help)
Biegeleisen, Ken (2016). "A New Histone Structure Which Binds DNA at Its Eight Subunit N-Termini". OALib. 03 (02): 1–20. doi:10.4236/oalib.1102386. ISSN 2333-9721.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Biegeleisen, Ken (2016). "The Probable Structure of "Form IV" (Alkali-Denatured Circular DNA)". OALib. 03 (10): 1–24. doi:10.4236/oalib.1103114. ISSN 2333-9721.{{cite journal}}: CS1 maint: unflagged free DOI (link)

T.Shafee(Evo&Evo)^talk 08:56, 23 July 2021 (UTC)[reply]

Semantic overlap.

I’d like to propose that the current “Protamine” article be divided into:

1. Protamine (spermatogenic protein) 
2. Protamine sulfate (pharmaceutical peptide)

“protamines” in spermatogenesis are small, arginine-rich nuclear proteins whose sole well-established role is to bind and massively condense DNA in elongating spermatids. By contrast, the protamine that shows up in insulin formulations (e.g. NPH insulin) is simply the same kind of basic peptide used pharmaceutically to form a zinc-protamine–insulin precipitate and thereby slow insulin’s absorption from the subcutaneous depot. The only thing relating them is the high level of Arginine residues. The two uses of the term are entirely distinct and therefore should have distinct articles. Combining these under one heading conflates fundamentally different molecules and leads to confusion in both the reproductive-biology and pharmacology communities. 2A06:C701:46B8:FF00:4137:1D20:640:3683 (talk) 10:09, 28 June 2025 (UTC)[reply]