C5a受体

C5a受体
識別號
别名	C5AR1；, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor, complement C5a receptor 1
外部ID	OMIM：113995 MGI：88232 HomoloGene：20413 GeneCards：C5AR1
基因位置（人类） 染色体 19號染色體 基因座 19q13.32 起始 47,290,023 bp 终止 47,322,066 bp
基因位置（小鼠） 染色体 小鼠7号染色体 基因座 7 A2|7 8.77 cM 起始 15,980,668 bp 终止 15,993,465 bp
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • complement component C5a binding • signal transducer activity • complement receptor activity • complement component C5a receptor activity • G protein-coupled receptor activity 細胞組分 • integral component of membrane • 膜 • 细胞膜 • apical part of cell • integral component of plasma membrane • cell surface • basolateral plasma membrane • cytoplasmic vesicle • secretory granule membrane 生物學過程 • negative regulation of neuron apoptotic process • positive regulation of epithelial cell proliferation • mRNA transcription by RNA polymerase II • activation of phospholipase C activity • neutrophil chemotaxis • positive regulation of angiogenesis • 趨化性 • cellular defense response • response to lipopolysaccharide • animal organ regeneration • 免疫反应 • response to peptidoglycan • positive regulation of ERK1 and ERK2 cascade • positive regulation of neutrophil chemotaxis • complement receptor mediated signaling pathway • sensory perception of chemical stimulus • positive regulation of vascular endothelial growth factor production • cell proliferation in hindbrain • positive regulation of macrophage chemotaxis • 訊息傳遞 • defense response to Gram-positive bacterium • 细胞凋亡 • regulation of complement activation • inflammatory response • phospholipase C-activating G protein-coupled receptor signaling pathway • neutrophil degranulation • leukocyte migration • cell chemotaxis • positive regulation of cytosolic calcium ion concentration • G protein-coupled receptor signaling pathway • complement component C5a signaling pathway • 認知 • regulation of astrocyte activation • presynapse organization • regulation of amyloid-beta clearance • regulation of tau-protein kinase activity • regulation of microglial cell activation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	728	12273
Ensembl	ENSG00000197405	ENSMUSG00000049130
UniProt	P21730	P30993
mRNA​序列	NM_001736	NM_001173550 ​NM_007577
蛋白序列	NP_001727	NP_001167021 ​NP_031603
基因位置​（UCSC）	Chr 19: 47.29 – 47.32 Mb	Chr 7: 15.98 – 15.99 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

C5a受体（英語：C5a receptor或称补体成分5a受体1，complement component 5a receptor 1，C5AR1或CD88，Cluster of Differentiation 88）是一种与补体C5a相结合的G蛋白偶联受体。

C5a受体结构及其与配体结合信号转导相关的氨基酸残基

细胞

C5a受体表达于以下细胞：

• 粒细胞
• 单核细胞
• 树突状细胞
• 肝癌细胞Hep G2以及由其衍生的肝癌细胞系
• 星形膠質細胞
• 小胶质细胞

另见

• 补体成分5a

延伸阅读

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• Beil WJ, Schulz M, Wefelmeyer U. Mast cell granule composition and tissue location--a close correlation.. Histol. Histopathol. 2001, 15 (3): 937–46. PMID 10963136. 
• Yamamoto T. Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes.. Pathol. Int. 2007, 57 (1): 1–11. PMID 17199736. doi:10.1111/j.1440-1827.2007.02049.x. 
• Bao L, Gerard NP, Eddy RL; et al. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.. Genomics. 1992, 13 (2): 437–40. PMID 1612600. doi:10.1016/0888-7543(92)90265-T.  引文格式1维护：显式使用等标签 (link)
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• Boulay F, Mery L, Tardif M; et al. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.. Biochemistry. 1991, 30 (12): 2993–9. PMID 2007135. doi:10.1021/bi00226a002.  引文格式1维护：显式使用等标签 (link)
• Wahl SM, Allen JB, Gartner S; et al. HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.. J. Immunol. 1989, 142 (10): 3553–9. PMID 2541200.  引文格式1维护：显式使用等标签 (link)
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• Buhl AM, Osawa S, Johnson GL. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.. J. Biol. Chem. 1995, 270 (34): 19828–32. PMID 7649993. doi:10.1074/jbc.270.34.19828. 
• Wennogle LP, Conder L, Winter C; et al. Stabilization of C5a receptor--G-protein interactions through ligand binding.. J. Cell. Biochem. 1994, 55 (3): 380–8. PMID 7962171. doi:10.1002/jcb.240550316.  引文格式1维护：显式使用等标签 (link)
• Gerard NP, Bao L, Xiao-Ping H; et al. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.. Biochemistry. 1993, 32 (5): 1243–50. PMID 8383526. doi:10.1021/bi00056a007.  引文格式1维护：显式使用等标签 (link)
• Ames RS, Li Y, Sarau HM; et al. Molecular cloning and characterization of the human anaphylatoxin C3a receptor.. J. Biol. Chem. 1996, 271 (34): 20231–4. PMID 8702752. doi:10.1074/jbc.271.34.20231.  引文格式1维护：显式使用等标签 (link)
• Werfel T, Zwirner J, Oppermann M; et al. CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.. J. Immunol. 1996, 157 (4): 1729–35. PMID 8759762.  引文格式1维护：显式使用等标签 (link)
• Höpken UE, Lu B, Gerard NP, Gerard C. The C5a chemoattractant receptor mediates mucosal defence to infection.. Nature. 1996, 383 (6595): 86–9. PMID 8779720. doi:10.1038/383086a0. 
• Chen Z, Zhang X, Gonnella NC; et al. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.. J. Biol. Chem. 1998, 273 (17): 10411–9. PMID 9553099. doi:10.1074/jbc.273.17.10411.  引文格式1维护：显式使用等标签 (link)
• Floreani AA, Heires AJ, Welniak LA; et al. Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.. J. Immunol. 1998, 160 (10): 5073–81. PMID 9590258.  引文格式1维护：显式使用等标签 (link)
• Ottonello L, Corcione A, Tortolina G; et al. rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.. J. Immunol. 1999, 162 (11): 6510–7. PMID 10352266.  引文格式1维护：显式使用等标签 (link)
• Kohleisen B, Shumay E, Sutter G; et al. Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.. AIDS. 2000, 13 (17): 2331–41. PMID 10597774. doi:10.1097/00002030-199912030-00004.  引文格式1维护：显式使用等标签 (link)
• Monk PN, Scola A-M, Madala P, Fairlie DP. Function, structure and therapeutic potential of complement C5a receptors. British Journal of Pharmacology. 2007, 152 (4): 429–48. PMC 2050825 . PMID 17603557. doi:10.1038/sj.bjp.0707332. 

外部链接

• Anaphylatoxin Receptors: C5a. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2014-04-07）. 
• 醫學主題詞表（MeSH）：C5a+receptors